Root 66 is your fast lane to the Midwest's premier cannabis shopping experience.  We offer a full suite of classic, curated and high-quality medical marijuana products without the high-end prices.  At Root 66 our unique and convenient customer experience will have you back on the "Mother Road" to wellness in no time flat.

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SOUTH GRAND

3737 S. Grand Blvd.
St. Louis, MO 63118

314-257-0816

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DOGTOWN

6660 Manchester Ave.
St. Louis, MO 63139

314-282-7978

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OPEN 04.20.21

ST. PETERS

3004 S. St. Peters Pkwy
St. Charles, MO 63303

636-373-8329

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